Necrosis of the skin and soft tissue typically affects obese, middle aged women on the third to fifth day of coumarin therapy, but in rare cases it can affect active men. This case report analyzes the affect of necrosis by measuring the pain, erythema, and ecchymoses of the skin to the formation of large hemorrhagic bullae with frank necrosis.

Download study: Necrosis and Gangrene as a Complication of Coumarin Therapy

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